| Saturday, May 2 | ||||
| Columbus Crew | at Toronto FC | 1-1 |  | 19,998 |
| FC Dallas | at D.C. United | DC 2, DAL 1 | | 14,225 |
| Seattle Sounders FC | at Chicago Fire | 1-1 | | 10,288 |
| Real Salt Lake | at Colorado Rapids | COL 2, RSL 0 | | 9,045 |
| Chivas USA | at San Jose Earthquakes | CHV 1, SJ 0 | | 10,049 |
| New York Red Bulls | at Los Angeles Galaxy | LA 1, NY 0 | | 21,006 |
| Sunday, May 3 | ||||
| Houston Dynamo | at New England Revolution | HOU 2, NE 0 | | 9,112 |
| Wednesday, May 6 | ||||
| D.C. United | at Kansas City Wizards | 1-1 | | 9,077 |
| Los Angeles Galaxy | at Real Salt Lake | 2-2 | | 16,155 |
| Friday, May 8 | ||||
| San Jose Earthquakes | at New York Red Bulls | NY 4, SJ 1 | | 8,042 |
| Saturday, May 9 | ||||
| Kansas City Wizards | at Columbus Crew | CLB 3, KC 2 | | 14,271 |
| Toronto FC | at D.C. United | 3-3 | | 15,652 |
| New England Revolution | at Chicago Fire | 1-1 | | 11,288 |
| FC Dallas | at Houston Dynamo | HOU 1, DAL 0 | | 16,932 |
| Real Salt Lake | at Chivas USA | CHV 1, RSL 0 | | 13,421 |
| Sunday, May 10 | ||||
| Los Angeles Galaxy | at Seattle Sounders FC | 1-1 | | 29,025 |
| Saturday, May 16 | ||||
| Chicago Fire | at Toronto FC | 4:00 p.m. |   | DK, Match Center |
| Colorado Rapids | at New England Revolution | 7:30 p.m. |  | DK, Match Center |
| Houston Dynamo | at New York Red Bulls | 7:30 p.m. | | DK, Match Center |
| Seattle Sounders FC | at FC Dallas | 8:30 p.m. | | DK, Match Center |
| Kansas City Wizards | at Real Salt Lake | 9:00 p.m. | | DK, Match Center |
| D.C. United | at Chivas USA | 11:00 p.m. | | FSC, FSE |
| Sunday, May 17 | ||||
| Columbus Crew | at Los Angeles Galaxy | 3:00 p.m. | | Telefutura |
| Saturday, May 23 | ||||
| New England Revolution | at Toronto FC | 4:00 p.m. | | DK, Match Center |
| Real Salt Lake | at D.C. United | 7:30 p.m. | | DK, Match Center |
| Chivas USA | at Kansas City Wizards | 8:30 p.m. | | FSC, FSE |
| Los Angeles Galaxy | at FC Dallas | 8:30 p.m. | | DK, Match Center |
| San Jose Earthquakes | at Houston Dynamo | 8:30 p.m. | | DK, Match Center |
| Seattle Sounders FC | at Colorado Rapids | 9:30 p.m. | | DK, Match Center |
| Sunday, May 24 | ||||
| Chicago Fire | at New York Red Bulls | 3:00 p.m. | | Telefutura |
| Wednesday, May 27 | ||||
| San Jose Earthquakes | at Columbus Crew | 7:30 p.m. | | DK, Match Center |
| Thursday, May 28 | ||||
| Chicago Fire | at Chivas USA | 10:30 p.m. | | ESPN2, Deportes |
| Saturday, May 30 | ||||
| Colorado Rapids | at New York Red Bulls | 7:30 p.m. | | DK, Match Center |
| D.C. United | at New England Revolution | 7:30 p.m. | | DK, Match Center |
| Toronto FC | at Houston Dynamo | 8:30 p.m. | | DK, Match Center |
| Columbus Crew | at Seattle Sounders FC | 10:30 p.m. | | FSC, FSE |
| Kansas City Wizards | at Los Angeles Galaxy | 10:30 p.m. | | DK, Match Center |
| Real Salt Lake | at San Jose Earthquakes | 10:30 p.m. | | DK, Match Center |
| Sunday, May 31 | ||||
| FC Dallas | at Chicago Fire | 3:00 p.m. | | Telefutura |