| away club | home club | time (ET) / result | ||
| Thursday, March 19 | ||||
| New York Red Bulls | at Seattle Sounders FC | SEA 3, NY 0 | ||
| Saturday, March 21 | ||||
| Columbus Crew | at Houston Dynamo | 1-1 | ||
| Chicago Fire | at FC Dallas | CHI 3, DAL 1 | ||
| Toronto FC | at Kansas City Wizards | TOR 3, KC 2 | ||
| Colorado Rapids | at Chivas USA | CHV 2, COL 1 | ||
| New England Revolution | at San Jose Earthquakes | NE 1, SJ 0 | ||
| Sunday, March 22 | ||||
| D.C. United | at Los Angeles Galaxy | 2-2 | ||
| Saturday, March 28 | ||||
| Toronto FC | at Columbus Crew | 1-1 | ||
| Chicago Fire | at D.C. United | 1-1 | ||
| New England Revolution | at New York Red Bulls | 1-1 | ||
| Kansas City Wizards | at Colorado Rapids | COL 2, KC 1 | ||
| Houston Dynamo | at San Jose Earthquakes | SJ 3, HOU 2 | ||
| Real Salt Lake | at Seattle Sounders FC | SEA 2, RSL 0 | ||
| Sunday, March 29 | ||||
| Chivas USA | at FC Dallas | CHV 2, DAL 0 | ||